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LC1207 Caffeinesuitable for use as excipient exp Ph Eur,BP,USP |
| Order number | Packaging | Quantity | Price € |
| AC28207 | Plastic bottle | 1 kg | inquire |
| AC28207 | Fibre carton | 50 kg | inquire |
| Product information | |
| Grade | Ph Eur,BP,USP |
| Synonyms | 7-Methyltheobromine, 1,3,7-Trimethylxanthine, 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione |
| Hill Formula | C8H10N4O2 |
| HS Code | 2939 30 00 |
| EC number | 200-362-1 |
| Molar mass | 194.19 g/mol |
| EC index number | 613-086-00-5 |
| CAS number | 58-08-2 |
| Chemical and physical data | |
| Ignition temperature | >600 °C |
| Solubility | 20 g/l (20 °C) |
| Melting point | 235 – 239 °C |
| Molar mass | 194.19 g/mol |
| Density | 1.23 g/cm3 (18 °C) |
| Bulk density | 300 – 600 kg/m3 |
| pH value | 5.5 – 6.5 (10 g/l, H2O, 20 °C) |
| Vapor pressure | 20 hPa (80 °C) |
| Safety information according to GHS | |
| Hazard Statement(s) | H301: Toxic if swallowed. |
| Signal Word | Danger |
| Hazard Pictogram(s) |  |
| Storage class | 10 – 13 Other liquids and solids |
| WGK | WGK 1 slightly water endangering |
| Disposal | 3 Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C. |
| Safety information | |
| R Phrase | R 22 Harmful if swallowed. |
| Categories of danger | harmful |
| Hazard Symbol |  Harmful |
| Transport information | |
| Declaration (transport by sea) IMDG-Code | UN 1544 ALCALOID SALTS, SOLID, N.O.S.(CAFFEINE), 6.1, III |
| Declaration (transport by air) IATA-DGR | UN 1544 ALCALOID SALTS, SOLID, N.O.S.(CAFFEINE), 6.1, III |
| Toxicological data | |
| LD 50 oral | LD50 rat 261 – 381 mg/kg |
| LD 50 dermal | LD50 rat > 2000 mg/kg |
| Specifications | |
| Assay – perchloric acid titration, calculated on dried substance |
98.5 – 101.0 % |
| – HPLC | 98.5 – 101.0 % |
| Identity | passes test |
| Appearance of solution (1 %; water) | passes test |
| Acidic substances | passes test |
| Sulphate (SO4) | ≤ 0.0500 % |
| Heavy metals (as Pb) | ≤ 0.001 % |
| Chloroform (HS-GC) | ≤ 60 ppm |
| related substances (HPLC, EP) – Highest single impurity |
≤ 0.10 % |
| – Sum of all impurities | ≤ 0.1 % |
| chromatographic purity (USP) – Highest single impurity |
≤ 0.10 % |
| – Sum of all impurities | ≤ 0.1 % |
| Theophylline (HPLC) | ≤ 0.10 % |
| Other residual solvents (Ph.Eur./USP/ICH) | excluded by production process |
| Sulfated ash | ≤ 0.1 % |
| Loss on drying (105 °C) | ≤ 0.5 % |
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