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LC1414 Cocarboxylase chloridethiamine diphosphoric acid ester chloride, suitable for use as an active pharmaceutical ingredient api |
| Order number | Packaging | Quantity | Price € |
| AC28414 | Plastic bottle | 1 kg | Inquire |
| AC28414 | Plastic bottle | 5 kg | Inquire |
| Product information | |
| Synonyms | Thiaminium diphosphoric acid ester chloride, Thiaminium pyrophosphate chloride, Thiaminium pyrophosphoric acid ester chloride, TPP |
| Hill Formula | C12H19ClN4O7P2S |
| HS Code | 2936 22 00 |
| EC number | 205-836-1 |
| Molar mass | 460.77 g/mol |
| CAS number | 154-87-0 |
| Chemical and physical data | |
| Solubility | 220 g/l (20 °C) |
| Melting point | 240 – 244 °C (decomposition) |
| Molar mass | 460.77 g/mol |
| Bulk density | 500 kg/m3 |
| pH value | 1.0 – 1.4 (100 g/l, H2O, 20 °C) |
| Safety information according to GHS | |
| Storage class | 10 – 13 Other liquids and solids |
| WGK | WGK 1 slightly water endangering |
| Specifications | |
| Assay (HPLC, calc. on dried substance) | ≥ 93.0 % |
| Identity (IR-spectrum) | passes test |
| Appearance of solution (10 %; water) | passes test |
| pH-value (10 %; water) | 1.0 – 1.4 |
| Chloride (Cl) (calculated on dried substance) | 7.5 – 7.9 % |
| Free phosphate (PO4) | ≤ 1.0 % |
| Sulphate (SO4) | ≤ 0.01 % |
| Heavy metals (as Pb) | ≤ 0.001 % |
| As (Arsenic) | ≤ 0.0003 % |
| Thiamin Monophosphoric Acid Ester Chloride (HPLC) | ≤ 4.0 % |
| Thiamin Dichloride (HPLC) | ≤ 0.5 % |
| Related substances (HPLC) | ≤ 1.5 % |
| Loss on drying (130 °C) | ≤ 1.5 % |
| Residual solvents (Ph.Eur./USP/ICH) class 2 (Methanol) | ≤ 2.0 % |
| Other residual solvents (Ph. Eur./USP/ICH) | excluded by manufacturing process |
| Endotoxins | ≤ 12 I.U./g |
| Microbiological test | passes test |
| Colony count – aerobic bacteria |
≤ 500 CFU/g |
| – Yeasts and moulds | ≤ 100 CFU/g |
| Salmonella species | In 10g substance not detectable |
| E.coli | In 1g substance not detectable |
| Staphylococcus aureus | In 1g substance not detectable |
| Pseudomonas aeruginosa | In 1g substance not detectable |
| Candida albicans | In 1g substance not detectable |
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