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LC1414 Cocarboxylase chloridethiamine diphosphoric acid ester chloride, suitable for use as an active pharmaceutical ingredient api |
Order number | Packaging | Quantity | Price € |
AC28414 | Plastic bottle | 1 kg | Inquire |
AC28414 | Plastic bottle | 5 kg | Inquire |
Product information | |
Synonyms | Thiaminium diphosphoric acid ester chloride, Thiaminium pyrophosphate chloride, Thiaminium pyrophosphoric acid ester chloride, TPP |
Hill Formula | C12H19ClN4O7P2S |
HS Code | 2936 22 00 |
EC number | 205-836-1 |
Molar mass | 460.77 g/mol |
CAS number | 154-87-0 |
Chemical and physical data | |
Solubility | 220 g/l (20 °C) |
Melting point | 240 – 244 °C (decomposition) |
Molar mass | 460.77 g/mol |
Bulk density | 500 kg/m3 |
pH value | 1.0 – 1.4 (100 g/l, H2O, 20 °C) |
Safety information according to GHS | |
Storage class | 10 – 13 Other liquids and solids |
WGK | WGK 1 slightly water endangering |
Specifications | |
Assay (HPLC, calc. on dried substance) | ≥ 93.0 % |
Identity (IR-spectrum) | passes test |
Appearance of solution (10 %; water) | passes test |
pH-value (10 %; water) | 1.0 – 1.4 |
Chloride (Cl) (calculated on dried substance) | 7.5 – 7.9 % |
Free phosphate (PO4) | ≤ 1.0 % |
Sulphate (SO4) | ≤ 0.01 % |
Heavy metals (as Pb) | ≤ 0.001 % |
As (Arsenic) | ≤ 0.0003 % |
Thiamin Monophosphoric Acid Ester Chloride (HPLC) | ≤ 4.0 % |
Thiamin Dichloride (HPLC) | ≤ 0.5 % |
Related substances (HPLC) | ≤ 1.5 % |
Loss on drying (130 °C) | ≤ 1.5 % |
Residual solvents (Ph.Eur./USP/ICH) class 2 (Methanol) | ≤ 2.0 % |
Other residual solvents (Ph. Eur./USP/ICH) | excluded by manufacturing process |
Endotoxins | ≤ 12 I.U./g |
Microbiological test | passes test |
Colony count – aerobic bacteria |
≤ 500 CFU/g |
– Yeasts and moulds | ≤ 100 CFU/g |
Salmonella species | In 10g substance not detectable |
E.coli | In 1g substance not detectable |
Staphylococcus aureus | In 1g substance not detectable |
Pseudomonas aeruginosa | In 1g substance not detectable |
Candida albicans | In 1g substance not detectable |
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