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LC1964 Ethyl 4-aminobenzoate (benzocaine),

suitable for use as an active pharmaceutical ingredient EMPROVE api Ph Eur,BP,USP

 

Order number Packaging Quantity Price €
AC28964 Glass bottle 1 kg Inquire
AC28964 Glass bottle 50 kg Inquire

 

Product information
Grade Ph Eur,BP,USP
Synonyms Benzocaine, 4-Aminobenzoic acid ethyl ester, Aethoform
Hill Formula C9H11NO2
HS Code 2922 49 85
EC number 202-303-5
Molar mass 165.19 g/mol
CAS number 94-09-7

 

Chemical and physical data
Ignition temperature >450 °C
Solubility 0.4 g/l (25 °C)
Melting point 89 – 92 °C
Molar mass 165.19 g/mol
Bulk density 320 kg/m3
Boiling point 172 °C (17.3 hPa)
Flash point 112 °C

 

Safety information according to GHS
Storage class H317: May cause an allergic skin reaction.
Precautionary Statement(s) P280: Wear protective gloves.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
Signal Word Warning
Hazard Pictogram(s)
Storage class 10 – 13 Other liquids and solids
WGK WGK 2 water endangering
Disposal 3
Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.

 

Safety information
R Phrase R 43
May cause sensitization by skin contact.
S Phrase S 24/25-37
Avoid contact with skin and eyes.Wear suitable gloves.
Categories of danger sensitizing
Hazard Symbol Irritant

 

Toxicological data
LD 50 oral LD50 rat 3042 mg/kg

 

Specifications
Assay Ph Eur/BP (calculated on dried substance) 99.0 – 101.0 %
Assay USP 99.0 – 101.0 %
Identity passes test
Appearance of solution passes test
Acidity or alkalinity passes test
Melting range
– lower value
≥ 89 °C
– upper value ≤ 92 °C
Chloride (Cl) conforms
Heavy metals (as Pb) ≤ 0.001 %
Readily carbonisable substance passes test
Methyl-4-aminobenzoate (HPLC) ≤ 0.10 %
Sum of all impurities (HPLC) ≤ 0.50 %
Residual solvents (Ph.Eur./USP/ICH) class 3 ≤ 0.5 %
Other residual solvents (Ph.Eur./USP/ICH) excluded by manufactoring process
Ordinary impurities (TLC) passes test
Sulfated ash ≤ 0.1 %
Loss on drying ≤ 0.5 %

 

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