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LC4064 Methyl 4-hydroxybenzoate sodium salt

suitable for use as excipient exp Ph Eur,BP,NF,E 219

 

Order number Packaging Quantity Price €
AC31064 Plastic bottle 5 kg inquire
AC31064 Double PE Sack 20 kg inquire

 

Product information
Grade Ph Eur,BP,NF,E 219
Synonyms 4-Hydroxybenzoic acid methyl ester sodium salt, Methylparaben sodium salt
Hill Formula C8H7NaO3
Chemical formula Na+[4-(O)C6H4(COOCH3)]
HS Code 2918 29 00
EC number 225-714-1
Molar mass 174.13 g/mol
CAS number 5026-62-0

 

Chemical and physical data
Ignition temperature >600 °C
Solubility 333 g/l (20 °C)
Melting point >125 °C
Molar mass 174.13 g/mol
Bulk density 700 kg/m3
pH value 9.7 – 10.3 (1 g/l, H2O)
Vapor pressure (20 °C)

 

Safety information according to GHS
Hazard Statement(s) H319: Causes serious eye irritation.
Precautionary Statement(s) P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Signal Word Warning
Hazard Pictogram(s)
Storage class 10 – 13 Other liquids and solids
WGK WGK 1 slightly water endangering
Disposal 3
Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.

 

Safety information
R Phrase R 36
Irritating to eyes.
Categories of danger irritant
Hazard Symbol Irritant

 

Transport information
Declaration (transport by sea) IMDG-Code No Dangerous Good
Declaration (transport by air) IATA-DGR No Dangerous Good

 

Toxicological data
LD 50 oral LD50 rat > 5000 mg/kg

 

Specifications
Assay
– acidimetric, calc. on anhydrous substance
99.5 – 101.5 %
– HPLC, calc.on anhydrous substance conforms
Identity passes test
Appearance of solution passes test
pH-value (0.1 %; water) 9.5 – 10.5
Chloride (Cl) ≤ 0.03 %
Sulphate (SO4) ≤ 0.03 %
Heavy metals (as Pb) ≤ 0.001 %
As (Arsenic) ≤ 0.0003 %
Cd (Cadmium) ≤ 0.001 %
Cu (Copper) ≤ 0.001 %
Hg (Mercury) ≤ 0.0001 %
Pb (Lead) ≤ 0.0005 %
Zn (Zinc) ≤ 0.001 %
Related substances (HPLC) conforms
p-Hydroxy benzoic acid ≤ 3.0 %
largest unspecified impurity ≤ 0.5 %
Sum of all impurities (without Impurity A of EP) ≤ 1.0 %
Methanol ≤ 3000 ppm
Residual solvents (Ph.Eur./USP/ICH) class 3 ≤ 0.5 %
Other residual solvents (Ph.Eur./USP/ICH) excluded by manufactoring process
Sulfated ash 39.5 – 44.5 %
Water ≤ 5.0 %
Residues of metal catalysts or metal reagents acc. to EMEA/C HMP/SWP/4446/2000 are not likely to be present.
Corresponds Ph Eur, BP,NF,E 219

 

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