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LC4192 Naphazoline nitrate

suitable for use as an active pharmaceutical ingredient api Ph Eur,BP

 

Order number Packaging Quantity Price €
AC31192 Plastic bottle 1 kg Inquire

 

Product information
Grade Ph Eur,BP
Synonyms 2-(1-Naphthylmethyl)imidazolinium nitrate
Hill Formula C14H15N3O3
HS Code 2933 29 10
EC number 225-915-4
Molar mass 273.29 g/mol
CAS number 5144-52-5

 

Chemical and physical data
Solubility 28 g/l (20 °C)
Melting point 167 – 170 °C
Molar mass 273.29 g/mol
Bulk density 550 kg/m3
pH value 5.0 – 6.5 (10 g/l, H2O, 20 °C)

 

Safety information according to GHS
Hazard Statement(s) H302: Harmful if swallowed.
Signal Word Warning
Hazard Pictogram(s)
Storage class 10 – 13 Other liquids and solids
WGK WGK 3 highly water endangering
Disposal 3
Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.

 

Safety information
R Phrase R 22
Harmful if swallowed.
Categories of danger harmful
Hazard Symbol Harmful

 

Toxicological data
LD 50 oral LD50 rat 1260 mg/kg

 

Specifications
Assay (perchloric acid titration, calculated on dried substance) 99.0 – 101.0 %
Identity (IR-spectrum) conforms
Appearance white or almost white, crystalline powder
Appearance of solution (10 g/l, water) clear and colourless
pH (10 g/l, water) 5.0 – 6.5
Chloride (Cl) ≤ 0.02 %
Residual solvents (Ph.Eur./USP/ICH) class 2 (Toluene) ≤ 80 ppm
Residual solvents (Ph.Eur./USP/ICH) class 3 (Acetone) ≤ 1000 ppm
Residual solvents (Ph. Eur./USP/ICH) of class 3 (Propan-2-ol) ≤ 5000 ppm
Diisopropylether ≤ 500 ppm
Other residual solvents (Ph. Eur./USP/ICH) excluded by the manufacturing process
Related substances (HPLC)
– Naphthylacetylethylenediamine
≤ 0.5 %
– Largest unspecified impurity ≤ 0.10 %
– Sum of all impurities ≤ 1.0 %
Sulfated ash (600 °C) ≤ 0.1 %
Loss on drying (105 °C) ≤ 0.5 %

 

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