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LC4727 Piperazine hexahydrate
suitable for use as excipient exp Ph Eur,BP


Order number Packaging Quantity Price €
AC31727 Plastic drum 50 kg Inquire


Product information
Grade Ph Eur,BP
Synonyms Diethylenediamine
Hill Formula C4H10N2 * 6 H2O
HS Code 2933 59 95
EC number 203-808-3
Molar mass 194.23 g/mol
EC index number 612-057-00-4
CAS number 142-63-2


Chemical and physical data
Ignition temperature >150 °C
Solubility 300 g/l (20 °C)
Melting point 43 – 45 °C
Molar mass 194.23 g/mol
Bulk density 440 kg/m3
pH value 10.8 – 11.8 (100 g/l, H2O, 20 °C)
Boiling point 105 °C (1013 hPa)
Vapor pressure 2.6 hPa (20 °C)
Flash point 87 °C


Safety information according to GHS
Hazard Statement(s) H361fd: Suspected of damaging fertility. Suspected of damaging the unborn child.
H314: Causes severe skin burns and eye damage.
H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled.
H317: May cause an allergic skin reaction.
Precautionary Statement(s) P280: Wear protective gloves/protective clothing/eye protection/face protection.
P301 + P330 + P331: IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304 + P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
Signal Word Danger
Hazard Pictogram(s)
Storage class Combustible substances, corrosive
WGK WGK 1 slightly water endangering
Disposal 3
Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.


Safety information
R Phrase R 34-42/43-62-63
Causes burns.May cause sensitization by inhalation and skin contact.Possible risk of impaired fertility.Possible risk of harm to the unborn child.
S Phrase S 22-26-36/37/39-45
Do not breathe dust.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing, gloves and eye/face protection.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Categories of danger corrosive, sensitizing, toxic for reproduction
Hazard Symbol



Transport information
Declaration (transport by sea) IMDG-Code UN 2579 PIPERAZINE, 8, III, Segregation Group: 18 (Alkalis)
Declaration (transport by air) IATA-DGR UN 2579 PIPERAZINE, 8, III


Toxicological data
LD 50 oral LD50 rat 500 mg/kg
LD 50 dermal LD50 rabbit 4000 mg/kg


Assay (perchloric acid titration) 98.0 – 101.0 %
Identity conforms
Appearance colorless, dissolving crystals
Appearance of solution (50 g/l CO2-free water) clear and not more intense in color than reference solution B8 (Ph. Eur.)
pH (50 g/l CO2-free water) 10.5 – 12.0
Heavy metals (as Pb) ≤ 0.002 %
Related substances (DC)
– Ethylenediamine
≤ 0.25 %
– Triethylenediamine ≤ 0.25 %
Residual solvents (Ph.Eur./ICH) excluded by manufacturing process
Sulfated ash (600 °C) ≤ 0.1 %