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LC5163 Procaine hydrochloride
suitable for use as an active pharmaceutical ingredient

 

Order number Packaging Quantity Price €
AC32163 Plastic bottle 1 kg inquire

 

Product information
Synonyms 2-Diethylamino-4-amino-benzoate hydrochloride
Hill Formula C13H21ClN2O2
Chemical formula C13H20N2O2 * HCl
HS Code 2922 49 85
EC number 200-077-2
Molar mass 272.77 g/mol
CAS number 51-05-8

 

Chemical and physical data
Solubility 1000 g/l (20 °C)
Melting point 155 – 158 °C
Molar mass 272.77 g/mol
Bulk density 600 kg/m3
pH value 5.0 – 6.0 (50 g/l, H2O, 20 °C)

 

Safety information according to GHS
Hazard Statement(s) H301: Toxic if swallowed.
Signal Word Danger
Hazard Pictogram(s)
Storage class 6.1A Combustible substances, toxic
Disposal 9
Carcinogenic compounds and flammable compounds labelled “Highly toxic” or “Toxic”: container F. Alkyl sulfates are carcinogenic; Take particular care to avoid inhalation and skin contact. To neutralize alkyl sulfates, add dropwise (from a dropping funnel) to concentrated ice-cool Ammonia solution (Cat.No. 105426) with vigorous stirring. Before placing in container D, check the pH with pH Universal indicator strips (Cat.No. 109535)

 

Safety information
R Phrase R 25
Toxic if swallowed.
S Phrase S 24-37-45
Avoid contact with skin.Wear suitable gloves.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Categories of danger toxic
Hazard Symbol Toxic

 

Transport information
Declaration (transport by sea) IMDG-Code UN 2811 TOXIC SOLID, ORGANIC, N.O.S.(PROCAINE HYDROCHLORIDE), 6.1, III
Declaration (transport by air) IATA-DGR UN 2811 TOXIC SOLID, ORGANIC, N.O.S.(PROCAINE HYDROCHLORIDE), 6.1, III

 

Toxicological data
LD 50 oral LD50 rat 200 mg/kg

 

Specifications
Assay (oxidimetrically; calc. on dried substance) 99.0 – 101.0 %
Identity passes test
Appearance of solution
– 5 %; water
passes test
– 10 %; water passes test
pH-value
– 2 %; water
5.0 – 6.0
– 5 %; water 5.0 – 6.0
Acid impurities passes test
Melting range
– lower value
≥ 155 °C
– upper value ≤ 158 °C
Heavy metals (as Pb) ≤ 0.0005 %
Related substances (TLC) passes test
Methanol (HS-GC) ≤ 3000 ppm
Toluene (HS-GC) ≤ 890 ppm
Residual solvents (Ph.Eur./USP/ICH) class 3 ≤ 0.5 %
Other residual solvents (Ph.Eur./USP/ICH) excluded by production process
Sulfated ash ≤ 0.1 %
Loss on drying (105 °C) ≤ 0.5 %
Endotoxine (gel-clot-test) ≤ 600 I.U./g