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LC4959 RiboflavinPh Eur,BP,JP,USP,E 101 (i) |
| Order number | Packaging | Quantity | Price € |
| AC31959 | Metal can | 2.5 kg | Inquire |
| AC31959 | Fibre carton | 10 kg | Inquire |
| Product information | |
| Grade | Ph Eur,BP,JP,USP,E 101 (i) |
| Synonyms | Lactoflavine, Vitamin B2 |
| Hill Formula | C17H20N4O6 |
| HS Code | 2936 23 00 |
| EC number | 201-507-1 |
| Molar mass | 376.36 g/mol |
| CAS number | 83-88-5 |
| Chemical and physical data | |
| Solubility | (20 °C) slightly soluble |
| Melting point | >300 °C |
| Molar mass | 214.04 g/mol |
| Bulk density | 620 kg/m3 |
| pH value | 5.5 – 7.2 (0.1 g/l, H2O, 20 °C) |
| Safety information | |
| Storage class | 10 – 13 Other liquids and solids |
| WGK | NWG not water endangering |
| Disposal | 3 Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C. |
| Toxicological data | |
| LD 50 oral | LD50 rat > 10000 mg/kg |
| LD 50 dermal | LD50 rat > 5000 mg/kg |
| Specifications | |
| Assay (spectrophotometrically; calc. on dried substance) | 98.0 – 102.0 % |
| Appearance | yellow to orange yellowish powder |
| Identity – TLC |
conforms |
| – Fluorescence test | conforms |
| – IR-spectrum | conforms |
| Absorbance maxima | at about 223 nm, 267 nm, 373 nm and 444 nm |
| Absorption ratio – A 373 nm / A 267 nm |
0.31 – 0.33 |
| – A 444 nm / A 267 nm | 0.36 – 0.39 |
| Spec. rotation [α]20/D – 5 g/l, sodium hydroxide (0.05 mol/l), calc. on dried substance, Ph. Eur. |
-135 – -115 ° |
| – 5 g/l, dilute sodium hydroxide and ethanol, calc. on dried substance, JP | -142 – -128 ° |
| Spec. rotation [α]25/D (5 g/l, sodium hydroxide (0.05 mol/l), calc. on dried substance, USP) | -135 – -115 ° |
| Primary aromatic amines (as Aniline) | ≤ 100 ppm |
| Heavy metals (as Pb) | ≤ 40 ppm |
| As (Arsenic) | ≤ 3 ppm |
| Cd (Cadmium) | ≤ 1 ppm |
| Hg (Mercury) | ≤ 1 ppm |
| Pb (Lead) | ≤ 10 ppm |
| Lumiflavin (USP) | passes test |
| Residual solvents (Ph.Eur./USP/ICH) class 2 (Methanol) | ≤ 3000 ppm |
| Residual solvents (Ph.Eur./USP/ICH) class 3 (3-Methyl-1-butanol) | ≤ 5000 ppm |
| Other residual solvents (Ph.Eur./USP/ICH) | excluded by production process |
| Related substances (HPLC) – Impurity A (Lumiflavin) |
≤ 0.025 % |
| – Impurity B | ≤ 0.20 % |
| – Impurity C | ≤ 0.20 % |
| – Impurity D | ≤ 0.20 % |
| – Largest unspecified impurity | ≤ 0.10 % |
| – Sum of all impurities | ≤ 0.5 % |
| Sulfated ash (600 °C) | ≤ 0.1 % |
| Loss on drying (105 °C) | ≤ 1.5 % |
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