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LC4959 RiboflavinPh Eur,BP,JP,USP,E 101 (i) |
Order number | Packaging | Quantity | Price € |
AC31959 | Metal can | 2.5 kg | Inquire |
AC31959 | Fibre carton | 10 kg | Inquire |
Product information | |
Grade | Ph Eur,BP,JP,USP,E 101 (i) |
Synonyms | Lactoflavine, Vitamin B2 |
Hill Formula | C17H20N4O6 |
HS Code | 2936 23 00 |
EC number | 201-507-1 |
Molar mass | 376.36 g/mol |
CAS number | 83-88-5 |
Chemical and physical data | |
Solubility | (20 °C) slightly soluble |
Melting point | >300 °C |
Molar mass | 214.04 g/mol |
Bulk density | 620 kg/m3 |
pH value | 5.5 – 7.2 (0.1 g/l, H2O, 20 °C) |
Safety information | |
Storage class | 10 – 13 Other liquids and solids |
WGK | NWG not water endangering |
Disposal | 3 Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C. |
Toxicological data | |
LD 50 oral | LD50 rat > 10000 mg/kg |
LD 50 dermal | LD50 rat > 5000 mg/kg |
Specifications | |
Assay (spectrophotometrically; calc. on dried substance) | 98.0 – 102.0 % |
Appearance | yellow to orange yellowish powder |
Identity – TLC |
conforms |
– Fluorescence test | conforms |
– IR-spectrum | conforms |
Absorbance maxima | at about 223 nm, 267 nm, 373 nm and 444 nm |
Absorption ratio – A 373 nm / A 267 nm |
0.31 – 0.33 |
– A 444 nm / A 267 nm | 0.36 – 0.39 |
Spec. rotation [α]20/D – 5 g/l, sodium hydroxide (0.05 mol/l), calc. on dried substance, Ph. Eur. |
-135 – -115 ° |
– 5 g/l, dilute sodium hydroxide and ethanol, calc. on dried substance, JP | -142 – -128 ° |
Spec. rotation [α]25/D (5 g/l, sodium hydroxide (0.05 mol/l), calc. on dried substance, USP) | -135 – -115 ° |
Primary aromatic amines (as Aniline) | ≤ 100 ppm |
Heavy metals (as Pb) | ≤ 40 ppm |
As (Arsenic) | ≤ 3 ppm |
Cd (Cadmium) | ≤ 1 ppm |
Hg (Mercury) | ≤ 1 ppm |
Pb (Lead) | ≤ 10 ppm |
Lumiflavin (USP) | passes test |
Residual solvents (Ph.Eur./USP/ICH) class 2 (Methanol) | ≤ 3000 ppm |
Residual solvents (Ph.Eur./USP/ICH) class 3 (3-Methyl-1-butanol) | ≤ 5000 ppm |
Other residual solvents (Ph.Eur./USP/ICH) | excluded by production process |
Related substances (HPLC) – Impurity A (Lumiflavin) |
≤ 0.025 % |
– Impurity B | ≤ 0.20 % |
– Impurity C | ≤ 0.20 % |
– Impurity D | ≤ 0.20 % |
– Largest unspecified impurity | ≤ 0.10 % |
– Sum of all impurities | ≤ 0.5 % |
Sulfated ash (600 °C) | ≤ 0.1 % |
Loss on drying (105 °C) | ≤ 1.5 % |
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